Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

Brad A. Friedman, Karpagam Srinivasan, Gai Ayalon, +11

Cell Reports

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Borislav Dejanovic, Melanie A. Huntley, Ann De Mazière, +14

Neuron

C1q AntibodiesSynaptic PlasticityNeurodegenerative DiseasesSignal TransductionAutoimmune Disease +9

An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

Alicia S. Chung, Xiumin Wu, Guanglei Zhuang, +9

Nature Medicine

InflammationCytokineCancer ImmunosurveillanceMedicineImmunology +6

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

Tiffany Wu, Borislav Dejanovic, Vineela Gandham, +18

Cell Reports

RIPK1 inhibits ZBP1-driven necroptosis during development

Kim Newton, Katherine E. Wickliffe, Allie Maltzman, +10

Nature

Developmental BiologyCell RegulationApoptosisZbp1-driven NecroptosisCell Death +4

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

Seung-Hye Lee, William J. Meilandt, Luke Xie, +14

Neuron

Neurodegenerative DiseasesAlzheimer's Diseaseβ-Amyloid PathologyTau AccumulationDegenerative Disease +6

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models

Borislav Dejanovic, Tiffany Wu, Ming‐Chi Tsai, +19

Nature Aging

Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem Cells<i>In Vivo</i>

Yosif Ganat, John Silbereis, Clinton Cave, +5

Journal of Neuroscience

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

William J. Meilandt, Hai Ngu, Alvin Gogineni, +16

Journal of Neuroscience

Synaptic SignalingPs2app AlzheimerSocial SciencesNeuroinflammationAlzheimer's Disease +19

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer

WeiYu Lin, Daqi Xu, Cary D. Austin, +45

Frontiers in Immunology