Immune dysregulation in human subjects with heterozygous germline mutations in <i>CTLA4</i>

Hye Sun Kuehn, Weiming Ouyang, Bernice Lo, +33

Science

ImmunodeficienciesGeneticsImmunologyT-regulatory CellPathology +19

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

C. Lucas, Hye Sun Kuehn, Fang Zhao, +25

Nature Immunology

T Cell SenescenceSignal TransductionCell RegulationImmunologyCellular Senescence +5

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

Valeria Facchinetti, Weiming Ouyang, Wei Hua, +12

The EMBO Journal

Mammalian TargetSignal TransductionProtein Kinase CSignaling PathwayMolecular Pathway +10

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

Weiming Ouyang, Omar Beckett, Qian Ma, +3

Nature Immunology

Transcriptional RegulationSystems BiologySignal TransductionT-regulatory CellCellular Regulatory Mechanism +4

Novel Foxo1-dependent transcriptional programs control Treg cell function

Weiming Ouyang, Will Liao, Chong Luo, +13

Nature

Transcriptional RegulationSignal TransductionTreg Cell FunctionGene RegulationRegulatory T Cells +6

An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and Tolerance

Weiming Ouyang, Omar Beckett, Richard A. Flavell, +1

Immunity

T Cell HomeostasisSignal TransductionEssential RoleT-regulatory CellImmunology +8

Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

Weiming Ouyang, Omar Beckett, Qian Ma, +1

Immunity

Developmental BiologyLymphocyte DevelopmentImmune Cell DevelopmentT-regulatory CellImmunology +10

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection

Myoungjoo V. Kim, Weiming Ouyang, Will Liao, +2

Immunity

Transcriptional RegulationT-regulatory CellPathogenesisImmunologyAutoimmunity +6

Essential roles of PI-3K/Akt/IKKβ/NFκB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells

Weiming Ouyang, Jingxia Li, Qian Ma, +1

Carcinogenesis

Cyclin D1 Induction through IκB Kinase β/Nuclear Factor-κB Pathway Is Responsible for Arsenite-Induced Increased Cell Cycle G1-S Phase Transition in Human Keratinocytes

Weiming Ouyang, Qian Ma, Jingxia Li, +4

Cancer Research