Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

C. Lucas, Hye Sun Kuehn, Fang Zhao, +25

Nature Immunology

T Cell SenescenceSignal TransductionCell RegulationImmunologyCellular Senescence +5

Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice

Fang Zhao, Robert A. Edwards, Diana Dizon, +6

Developmental Biology

Signal TransductionGoblet Cell HomeostasisCell RegulationCellular BiologyAgr2−/− Mice +8

The Receptor Ly108 Functions as a SAP Adaptor-Dependent On-Off Switch for T Cell Help to B Cells and NKT Cell Development

Robin Kageyama, Jennifer L. Cannons, Fang Zhao, +5

Immunity

T Cell HelpSignal TransductionLymphocyte DevelopmentImmune Cell DevelopmentNkt Cell Development +10

The extracellular lipase EXL4 is required for efficient hydration of Arabidopsis pollen

Emily P. Updegraff, Fang Zhao, Daphne Preuss

Sexual Plant Reproduction

Plant Molecular BiologyEfficient HydrationBiochemistryNatural SciencesMolecular Biology +5

Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis

Fang Zhao, Jennifer L. Cannons, Mala Dutta, +2

Immunity

Molecular PhysiologySignal TransductionSignaling PathwayCell InteractionNegative Signaling +9

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

Yuanming Xu, Fang Zhao, Quan Qiu, +13

Nature Communications

Adaptive Immune SystemT-regulatory CellImmunologyImmune RegulationCell Death +23

Syntaxin 11 is required for NK and CD8⁺ T‐cell cytotoxicity and neutrophil degranulation

Orietta D’Orlando, Fang Zhao, Brigitte Kasper, +6

European Journal of Immunology

MedicineImmunologyImmune RegulationCell DeathImmunologic Mechanism +11

STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5

Valentina Cetica, Alessandra Santoro, Kimberly Gilmour, +9

Journal of Medical Genetics

Lipidomic changes during different growth stages of Nitzschia closterium f. minutissima

Jilin Xu, Xiaojun Yan, Peng Zhao, +4

Metabolomics

BiologyDifferent Growth StagesFungal PhysiologyFungal BiologyMicrobiology +1

The Serine-threonine Kinase Inositol-requiring Enzyme 1α (IRE1α) Promotes IL-4 Production in T Helper Cells

Kyeorda Kemp, Zhenghong Lin, Fang Zhao, +4

Journal of Biological Chemistry