Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis

T cell receptor antagonist peptides induce positive selection

Kristin A. Hogquist, Stephen C. Jameson, William R. Heath et al. · Cell · 1994 · 2.9K citations

Life Sciences, Immunology, Molecular Biology +13

Three-dimensional segregation of supramolecular activation clusters in T cells

Colin R. F. Monks, Benjamin A. Freiberg, Hannah Kupfer et al. · Nature · 1998 · 2.3K citations

Life Sciences, Cell Biology, Molecular Biology +16

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

Joan Sayós, Chengbin Wu, M. Morra et al. · Nature · 1998 · 942 citations

Life Sciences, Immunology, Molecular Biology +10

Munc13-4 Is Essential for Cytolytic Granules Fusion and Is Mutated in a Form of Familial Hemophagocytic Lymphohistiocytosis (FHL3)

Jérôme Feldmann, Isabelle Callebaut, Graça Raposo et al. · Cell · 2003 · 927 citations · Full text

Medicine, Cell Biology, Molecular Genetics +5

T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation Cluster

Rajat Varma, Gabriele Campi, Tadashi Yokosuka et al. · Immunity · 2006 · 878 citations · Full text

Life Sciences, Cell Biology, Immunology +16