Fredrik Johansson

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos et al. · Nature · 2006 · 1.9K citations

Oncogene-induced Senescence, Chromatin, Genome Instability +11

PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination

Helen E. Bryant, Eva Petermann, Niklas Schultz et al. · The EMBO Journal · 2009 · 589 citations · Full text

Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Randi G. Syljuåsen, Claus Storgaard Sørensen, Lasse Tengbjerg Hansen et al. · Molecular and Cellular Biology · 2005 · 548 citations · Full text

Chromatin, Genome Instability, Human Chk1 Causes +11

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Helge Gad, Tobias Koolmeister, Ann‐Sofie Jemth et al. · Nature · 2014 · 525 citations

Tumor Biology, Dntp Pool, Mth1 Inhibition +8

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

Cecilia Ström, Fredrik Johansson, Mathias Uhlén et al. · Nucleic Acids Research · 2010 · 295 citations · Full text

Rna Processing, Genome Instability, Parp Inhibition +10