José L. Castro

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

Ruth M. McKernan, T.W. Rosahl, David S. Reynolds et al. · Nature Neuroscience · 2000 · 941 citations

Medicine, Neuroscience, Pharmacology +14

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Yue‐Ming Li, Min Xu, Ming‐Tain Lai et al. · Nature · 2000 · 869 citations

Life Sciences, Biochemistry, Molecular Biology +14

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity

Mark S. Shearman, Dirk Beher, Earl E. Clarke et al. · Biochemistry · 2000 · 367 citations

Life Sciences, Neurobiology, Neuroscience +17

Evidence for a Significant Role of α3-Containing GABA_AReceptors in Mediating the Anxiolytic Effects of Benzodiazepines

Rebecca Dias, Wayne F. A. Sheppard, Rosa Fradley et al. · Journal of Neuroscience · 2005 · 246 citations · Full text

Medicine, Pharmacology, Psychiatry +15

TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2 H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for α2- and α3-Containing GABAA Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates

John Atack, Keith A. Wafford, Spencer J. Tye et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 189 citations

Medicine, Medicinal Chemistry, Pharmacology +17