Spencer J. Tye

Evidence for a Significant Role of α3-Containing GABA_AReceptors in Mediating the Anxiolytic Effects of Benzodiazepines

Rebecca Dias, Wayne F. A. Sheppard, Rosa Fradley et al. · Journal of Neuroscience · 2005 · 244 citations · Full text

Anesthetic Mechanism, Psychopharmacology, Pharmacotherapy +19

TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2 H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for α2- and α3-Containing GABAA Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates

John Atack, Keith A. Wafford, Spencer J. Tye et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 187 citations

The novel NK1 receptor antagonist MK–0869 (L–754,030) and its water soluble phosphoryl prodrug, L–758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets

F.D. Tattersall, Wayne Rycroft, M. Cumberbatch et al. · Neuropharmacology · 2000 · 136 citations

Molecular Pharmacology, Signaling Pathway, Cisplatin-induced Emesis +7

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

Anthony L. Gotter, Christopher J. Winrow, Joseph Brunner et al. · BMC Neuroscience · 2013 · 93 citations · Full text

Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition

Jason M. Uslaner, Spencer J. Tye, Donnie Eddins et al. · Science Translational Medicine · 2013 · 89 citations

Sleep Disorders, Current Treatments, Psychotropic Medication +24