SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes

Kristin Verschueren, Jacques Remacle, Clara Collart, +9

Journal of Biological Chemistry

Activation of NF-κB by Akt upregulates Snail expression and induces epithelium mesenchyme transition

Sylvia Julien, Isabel Puig, Elena Caretti, +7

Oncogene

InflammationMesenchyme TransitionSignal TransductionMolecular PhysiologySignaling Pathway +8

Mice Lacking Zfhx1b, the Gene That Codes for Smad-Interacting Protein-1, Reveal a Role for Multiple Neural Crest Cell Defects in the Etiology of Hirschsprung Disease–Mental Retardation Syndrome

Tom Van de Putte, Mitsuji Maruhashi, Annick Francis, +4

The American Journal of Human Genetics

Developmental BiologySynaptic SignalingGenetic DisorderGeneticsMice Lacking Zfhx1b +8

Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases

Luc Van Rompaey, René Galien, Ellen M. van der Aar, +14

The Journal of Immunology

ImmunologyImmunologic MechanismImmune DysregulationInflammationPreclinical Characterization +17

Primary structure of human alpha 2-antiplasmin, a serine protease inhibitor (serpin).

William E. Holmes, L Nelles, H.R. Lijnen, +1

Journal of Biological Chemistry

Nucleotide sequence of a crustacean 18S ribosomal RNA gene and secondary structure of eukaryotic small subunit ribosoraal RNAs

L Nelles, Bao-Ling Fang, Guido Volckaert, +2

Nucleic Acids Research

Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634

Christel Menet, Stephen R. Fletcher, Guy Van Lommen, +16

Journal of Medicinal Chemistry

Drug TargetHit IdentificationJanus KinasesImmunologyPharmacotherapy +24

Characterization of recombinant human single chain urokinase-type plasminogen activator mutants produced by site-specific mutagenesis of lysine 158.

L Nelles, H.R. Lijnen, D Collen, +1

Journal of Biological Chemistry

Generation of the floxed allele of the SIP1 (<i>Smad‐interacting protein 1</i>) gene for Cre‐mediated conditional knockout in the mouse

Yujiro Higashi, Mitsuji Maruhashi, L Nelles, +6

genesis

Knockout MouseTranscriptional RegulationMolecular PhysiologyMolecular RegulationGenetics +8

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic

Mathieu Pizzonero, Sonia Dupont, Marielle Babel, +28

Journal of Medicinal Chemistry

InflammationFrom HitMedicinal ChemistryAnti-inflammatoryBiochemistry +13