DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells

Marie‐France Robert, Steves Morin, Normand Beaulieu, +4

Nature Genetics

ChromatinEpigenetic ChangeDna MethylationCpg MethylationEpigenomics +10

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Marielle Fournel, Claire Bonfils, Yu Hou, +17

Molecular Cancer Therapeutics

Tumor BiologyInhibitory ActivityMedicineHdac IsotypePharmacology +11

The Adipose Tissue Phenotype of Hormone‐Sensitive Lipase Deficiency in Mice

Shu Pei Wang, Nancy Laurin, Jean Himms‐Hagen, +6

Obesity Research

An Essential Role for DNA Methyltransferase DNMT3B in Cancer Cell Survival

Normand Beaulieu, Steves Morin, Ian C. Chute, +3

Journal of Biological Chemistry

N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)

Martin Allan, Sukhdev Manku, Éric Therrien, +11

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineMechanism Of ActionArginine Methyltransferase 1Drug Development +3

Development of Potential Antitumor Agents. Synthesis and Biological Evaluation of a New Set of Sulfonamide Derivatives as Histone Deacetylase Inhibitors

Giliane Bouchain, Silvana Leit, Sylvie Fréchette, +14

Journal of Medicinal Chemistry

PharmacotherapyHdac ActivityPharmaceutical ChemistryTumor BiologyMedicinal Chemistry +16

Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases

Stephen Claridge, Franck Raeppel, Marie‐Claude Granger, +23

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryVegfr2 Tyrosine KinasesMedicineNatural Sciences +9

N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: A novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors

Michael R. Mannion, Stéphane Raeppel, Stephen Claridge, +20

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetNovel SeriesBiochemistryMedicine +10

1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1)

Éric Therrien, Guillaume Larouche, Sukhdev Manku, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesMedicineMechanism Of Action +5

Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Clinical Course and Description of Causal Mutations in Two Patients

Luigi Bouchard, Marie‐France Robert, Dmitriy A. Vinarov, +12

Pediatric Research

Mitochondrial MyopathyClinical CourseMendelian DisorderMitochondrial BiogenesisMitochondrial Function +7