Discovery of (10 <i>R</i> )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- <i>2H</i> -8,4-(metheno)pyrazolo[4,3- <i>h</i> ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

Ted W. Johnson, Paul Richardson, Simon Bailey, +30

Journal of Medicinal Chemistry

PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models

Helen Y. Zou, Luc Friboulet, David P. Kodack, +30

Cancer Cell

Drug TargetHealth SciencesPreclinical ModelsMedicineRational Drug Design +8

Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance

Ping Chen, Nathan V. Lee, Wenyue Hu, +11

Molecular Cancer Therapeutics

Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib

Qinhua Huang, Ted W. Johnson, Simon Bailey, +38

Journal of Medicinal Chemistry

Aminopyridine 8ETumor BiologyKinase DomainNovel TherapyMedicine +12

Transforming growth factor beta 1 is an inducer of erythroid differentiation.

Gerald Krystal, Vivian Lam, Wieslawa H. Dragowska, +7

The Journal of Experimental Medicine

Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer

Shikhar Sharma, Chi‐Yeh Chung, Sean Uryu, +76

Cell chemical biology

Azaindole Hydroxamic Acids are Potent HIV-1 Integrase Inhibitors

Michael Plewe, Scott L. Butler, Klaus Dress, +14

Journal of Medicinal Chemistry

Hiv-1 In InhibitorsMedicinal ChemistryHiv-1 IntegraseBioorganic ChemistryHiv-1 In Enzyme +13

Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors

Kevin K.‐C. Liu, Simon Bailey, Dac M. Dinh, +5

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryNatural SciencesMedicine +9

Estrogen Treatment Induces Elevated Expression of HMG1 in MCF-7 Cells

Kai‐Yin Chau, Hieu Lam, Kam‐Len Daniel Lee

Experimental Cell Research

Hormonal ReceptorMcf-7 CellsImmunologyTumor SuppressorOvarian Hormone +8

Evaluation of spent medium recycle and nutrient feeding strategies for recombinant protein production in the insect cell–baculovirus process

Jian‐Yong Wu, Qian Ruan, Hieu Lam

Journal of Biotechnology

Viral ReplicationSpent Medium RecycleBiomanufacturingInsect VirusBiotechnology +5