Patrick K. Clark

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

Kalyan Das, Arthur D. Clark, Paul Lewi et al. · Journal of Medicinal Chemistry · 2004 · 511 citations

Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations

Alfredo Jacobo‐Molina, Raymond G. Nanni, Roger Williams et al. · Nature · 1992 · 187 citations

Virus Structure, Viral Replication, Viral Polymerase Structure +12

Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant

Kalyan Das, Jianping Ding, Y. Hsiou et al. · Journal of Molecular Biology · 1996 · 187 citations

Wild-type Hiv-1 Rt, Biochemistry, 9-Cl Tibo Complexed +12

Structures of HIV-1 RT–DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

Steve Tuske, Stefan G. Sarafianos, Arthur D. Clark et al. · Nature Structural & Molecular Biology · 2004 · 161 citations

Natural Sciences, Human Retrovirus, Immunology +11

HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

D.M. Himmel, Stefan G. Sarafianos, Sanjeewa Dharmasena et al. · ACS Chemical Biology · 2006 · 141 citations · Full text

Viral Replication, Viral Polymerase Structure, Novel Site +22