A-803467, a potent and selective Na _v 1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat

Michael F. Jarvis, Prisca Honoré, Char‐Chang Shieh, +34

Proceedings of the National Academy of Sciences

A rat brain na+ channel α subunit with novel gating properties

Vanessa J. Auld, Alan L. Goldin, Douglas S. Krafte, +6

Neuron

Molecular NeuroscienceMolecular PhysiologyHyperpolarization (Biology)NeurophysiologySodium Homeostasis +10

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Ken McCormack, Sonia Santos, Mark L. Chapman, +15

Proceedings of the National Academy of Sciences

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

Aristos J. Alexandrou, Adam R. Brown, Mark L. Chapman, +25

PLoS ONE

Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states

S. K. Joshi, Joseph P. Mikusa, Gricelda Hernandez, +12

Pain

Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Na_v1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain

Michael E. Kort, Irene Drizin, Robert J. Gregg, +27

Journal of Medicinal Chemistry

Pain DisordersPain MedicineNeuropathic PainMolecular PainPharmacotherapy +18

Distribution and functional properties of human KCNH8 (Elk1) potassium channels

Anruo Zou, Zhixin Lin, Margaret M. Humble, +5

American Journal of Physiology-Cell Physiology

Elk SubfamilyKcnh8 SubunitsNeurotransmissionCellular PhysiologySocial Sciences +17

A-887826 is a structurally novel, potent and voltage-dependent Nav1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats

Xu‐Feng Zhang, Char‐Chang Shieh, Mark L. Chapman, +10

Neuropharmacology

Molecular PharmacologyNeurophysiologySodium HomeostasisSynaptic TransmissionPhysiology +8

Direct Activation of an Inwardly Rectifying Potassium Channel by Arachidonic Acid

Yi Liu, Dong Liu, Louise Heath, +6

Molecular Pharmacology

A comprehensive approach to identifying repurposed drugs to treat <i><scp>SCN</scp>8A</i> epilepsy

Talia A. Atkin, Chani M. Maher, Aaron C. Gerlach, +13

Epilepsia