James J. Gibbons

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

Mehran S. Neshat, Ingo K. Mellinghoff, Chris Tran et al. · Proceedings of the National Academy of Sciences · 2001 · 973 citations · Full text

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.

Jennifer M. Golas, Kim Arndt, Carlo Etienne et al. · PubMed · 2003 · 414 citations

K562 Xenografts, Mixed-phenotype Acute Leukemia, Apoptosis +18

Biochemical, Cellular, and <i>In vivo</i> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin

Ker Yu, Lourdes Toral‐Barza, Celine Shi et al. · Cancer Research · 2009 · 326 citations

Chemoprevention Strategy, Cellular Pharmacology, Selective Inhibitors +22

Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound <b>26</b> (PKI-587), a Highly Efficacious Dual Inhibitor

Aranapakam M. Venkatesan, Christoph M. Dehnhardt, Efren Delos Santos et al. · Journal of Medicinal Chemistry · 2010 · 210 citations · Full text

Synthesis and SAR of [1,2,4]Triazolo[1,5-<i>a</i>]pyrimidines, a Class of Anticancer Agents with a Unique Mechanism of Tubulin Inhibition

Nan Zhang, Semiramis Ayral‐Kaloustian, Thai Nguyen et al. · Journal of Medicinal Chemistry · 2006 · 209 citations

Combinatorial Chemistry, Bioorganic Chemistry, Organic Chemistry +20