A L Jackman

Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.

G R Westerhof, Jan H. Schornagel, Ietje Kathmann et al. · Molecular Pharmacology · 1995 · 205 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid cells

Robert Jackson, A L Jackman, A H Calvert · Biochemical Pharmacology · 1983 · 111 citations

Life Sciences, Biochemistry, Pharmacology +9

Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems.

G R Westerhof, Gerrit Jansen, Nancy van Emmerik et al. · PubMed · 1991 · 75 citations

Medicine, Biochemistry, Pharmacology +12

Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors.

Stephen Clarke, Janet Hanwell, M. de Boer et al. · Journal of Clinical Oncology · 1996 · 74 citations

Pharmacy, Oncology, Pharmacology +12

Formation and retention and biological activity of N10-propargyl-5, 8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro

Ewa Sikora, A L Jackman, David R. Newell et al. · Biochemical Pharmacology · 1988 · 63 citations

Medicine, Biochemistry, Pharmacology +7