Jeffrey L. Hirsch

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

Debra M. Meyer, Michael I. Jesson, Xiong Li et al. · Journal of Inflammation · 2010 · 459 citations · Full text

Medicine, Immunology, Pharmacology +17

Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

Jill Chrencik, Akshay Patny, Iris Leung et al. · Journal of Molecular Biology · 2010 · 226 citations

Life Sciences, Biochemistry, Molecular Biology +14

Internal deletion in a collagen gene in a perinatal lethal form of osteogenesis imperfecta

Mon‐Li Chu, Charlene J. Williams, Gugliemina Pepe et al. · Nature · 1983 · 179 citations

Medicine, Genetics, Molecular Genetics +17

A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor α Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation

Robert J. Mourey, Barry Burnette, Sarah J. Brustkern et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 130 citations · Full text

Medicine, Immunology, Pharmacology +17

Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals

Chun Wang, Susan L. Hockerman, E. Jon Jacobsen et al. · The Journal of Experimental Medicine · 2018 · 104 citations · Full text

Life Sciences, Immunology, Pharmacology +17