TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

Kazuhito Naka, Takayuki Hoshii, Teruyuki Muraguchi, +6

Nature

Hematological MalignancyMedicineHematologyTgf-β–foxo SignallingCell Biology +2

Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway

Yuko Tadokoro, Kentaro Yomogida, Hiroshi Ohta, +2

Mechanisms of Development

Embryonic Stem CellHomeostatic RegulationDevelopmental BiologyGerm Cell FateCell Division +8

Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells

Shintaro Tanimura, Yuko Tadokoro, K Inomata, +10

Cell stem cell

Developmental BiologyMedicineAdult Stem CellMelanocyte Stem CellsMorphogenesis +6

Two mouse piwi-related genes: miwi and mili

Satomi Kuramochi‐Miyagawa, Tohru Kimura, Kentaro Yomogida, +6

Mechanisms of Development

GeneticsGenetic MechanismGene CharacterizationMolecular GeneticsPiwi-related Genes +3

De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells

Yuko Tadokoro, Hideo Ema, Masaki Okano, +2

The Journal of Experimental Medicine

Adult mouse hematopoietic stem cells: purification and single-cell assays

Hideo Ema, Yohei Morita, Satoshi Yamazaki, +6

Nature Protocols

MedicineAdult Stem CellHematologyStem Cell ResearchStem Cells +3

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

Yuko Kato, Atsushi Iwama, Yuko Tadokoro, +7

The Journal of Experimental Medicine

Active Stat MutantsImmunologyBlood CellLeukemic HematopoiesisSelective Activation +14

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

Jun Seita, Hideo Ema, Jun Ooehara, +6

Proceedings of the National Academy of Sciences

Lymphocyte DevelopmentThrombopoietin-mediated Signal TransductionAdult Stem CellImmunologyStem Cell Biology +14

mTORC1 is essential for leukemia propagation but not stem cell self-renewal

Takayuki Hoshii, Yuko Tadokoro, Kazuhito Naka, +7

Journal of Clinical Investigation

Mtorc1 AffectsMixed-phenotype Acute LeukemiaMtorc1 ActivityImmunologyLeukemia Propagation +16

Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells

Takayuki Hoshii, Atsuo Kasada, Tomoki Hatakeyama, +11

Proceedings of the National Academy of Sciences