Chad Bennett

Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo

Z. J. Sun, Theodros Asberom, Thomas Bara et al. · Journal of Medicinal Chemistry · 2011 · 52 citations · Full text

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

Xianhai Huang, Wei Zhou, Xiaoxiang Liu et al. · ACS Medicinal Chemistry Letters · 2012 · 37 citations · Full text

Neurochemical Biomarkers, Pharmacotherapy, Fused Oxadiazine Core +19

Iminoheterocycles as γ-secretase modulators

John P. Caldwell, Chad Bennett, Troy McCracken et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 29 citations · Full text

Molecular Pharmacology, Protein Secretion, Biochemistry +3

Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain

Chad Bennett, Duane A. Burnett, William J. Greenlee et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 24 citations · Full text

Pain Therapy, Pain Research, Tricyclic Mglur1 Antagonists +13

Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

Ruo Xu, David Cole, Ted Asberom et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 16 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Biochemistry +11