A dietary colorant crocin mitigates arthritis and associated secondary complications by modulating cartilage deteriorating enzymes, inflammatory mediators and antioxidant status

Mahadevappa Hemshekhar, M. Sebastin Santhosh, K. Sunitha, +4

Biochimie

InflammationRheumatologyRheumatoid DisorderMusculoskeletal ResearchAnti-inflammatory +13

Melatonin elevates apoptosis in human platelets via ROS mediated mitochondrial damage

Kesturu S. Girish, Manoj Paul, Ram M. Thushara, +4

Biochemical and Biophysical Research Communications

InflammationMitophagyHuman PlateletsMitochondrial DamageMitochondrial Function +8

Unconjugated Bilirubin exerts Pro-Apoptotic Effect on Platelets via p38-MAPK activation

Somanathapura K. NaveenKumar, Ram M. Thushara, Mahalingam S. Sundaram, +9

Scientific Reports

Crocin, a dietary additive protects platelets from oxidative stress-induced apoptosis and inhibits platelet aggregation

Ram M. Thushara, Mahadevappa Hemshekhar, M. Sebastin Santhosh, +5

Molecular and Cellular Biochemistry

InflammationThrombosisThrombopoiesisBlood PlateletMedicine +10

Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide

Manoj Paul, Mahadevappa Hemshekhar, Ram M. Thushara, +13

PLoS ONE

Lipid PeroxidationApoptosisCell DeathCell Death MechanismsRedox Biology +18

Tamarind Seed (Tamarindus indica) Extract Ameliorates Adjuvant-Induced Arthritis via Regulating the Mediators of Cartilage/Bone Degeneration, Inflammation and Oxidative Stress

Mahalingam S. Sundaram, Mahadevappa Hemshekhar, M. Sebastin Santhosh, +9

Scientific Reports

Snake Venom Induced Local Toxicities: Plant Secondary Metabolites as an Auxiliary Therapy

M. Sebastin Santhosh, Mahadevappa Hemshekhar, K. Sunitha, +4

Mini-Reviews in Medicinal Chemistry

Auxiliary TherapyToxinologyBiochemistryMedicineVenomics +9

<i>Vipera russelli</i> venom‐induced oxidative stress and hematological alterations: Amelioration by crocin a dietary colorant

M. Sebastin Santhosh, Mahadevappa Hemshekhar, Ram M. Thushara, +2

Cell Biochemistry and Function

Sesamol Ameliorates Cyclophosphamide-Induced Hepatotoxicity by Modulating Oxidative Stress and Inflammatory Mediators

S. Jnaneshwari, Mahadevappa Hemshekhar, Ram M. Thushara, +6

Anti-Cancer Agents in Medicinal Chemistry

A New Ibuprofen Derivative Inhibits Platelet Aggregation and ROS Mediated Platelet Apoptosis

K. S. Rakesh, Swamy Jagadish, A. C. Vinayaka, +11

PLoS ONE

InflammationThrombosisMedicinal ChemistryThrombopoiesisAnti-inflammatory +13