T. O'Reilly

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

J M Wood, Guido Bold, Elisabeth Buchdunger et al. · PubMed · 2000 · 847 citations

Medicine, Oncology, Pharmacology +16

Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes.

Marcel Loetscher, Thomas Geiser, T. O'Reilly et al. · Journal of Biological Chemistry · 1994 · 451 citations · Full text

Life Sciences, Immunology, Molecular Biology +14

Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class.

John A. Alberta, P R Zdunek, Melih Acar et al. · PubMed · 2000 · 310 citations

Medicine, Oncology, Pharmacology +14

A rat model of bone cancer pain

Stephen J. Medhurst, Katherine Walker, M. Bowes et al. · Pain · 2002 · 307 citations

Medicine, Cancer Biology, Bone Metabolism +15

PKC412--a protein kinase inhibitor with a broad therapeutic potential.

D Fabbro, Stephan Ruetz, Stephan Bodis et al. · PubMed · 2000 · 270 citations

Medicine, Oncology, Pharmacology +15