K. Boxall

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

Kwai-Ming J. Cheung, Thomas P. Matthews, Karen James et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 219 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Trans‐activation of the DNA‐damage signalling protein kinase Chk2 by T‐loop exchange

Antony W. Oliver, Angela Paul, K. Boxall et al. · The EMBO Journal · 2006 · 144 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors

Victoria E. Anderson, Michael I. Walton, Paul D. Eve et al. · Cancer Research · 2011 · 112 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +15

8-Substituted Pyrido[3,4-<i>d</i>]pyrimidin-4(3<i>H</i>)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Vassilios Bavetsias, Rachel M. Lanigan, G.F. Ruda et al. · Journal of Medicinal Chemistry · 2016 · 98 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D

Sydonia Rayter, Richard Elliott, Jon Travers et al. · Oncogene · 2007 · 84 citations

Medicine, Medicinal Chemistry, Pharmacology +9