WRN helicase is a synthetic lethal target in microsatellite unstable cancers

Edmond M. Chan, Tsukasa Shibue, James M. McFarland, +38

Nature

Microsatellite Unstable CancersOncogenic AgentMedicineMolecular BiologyCancer Genomics +6

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells

Jiancong Liang, Ma Wan, Yi Zhang, +8

Nature Cell Biology

Transcriptional RegulationInduced Pluripotent Stem CellDevelopmental BiologyMedicineNatural Sciences +7

Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development

Peili Gu, Bryan Goodwin, Arthur Chung, +10

Molecular and Cellular Biology

Orphan Nuclear Receptor GCNF Is Required for the Repression of Pluripotency Genes during Retinoic Acid-Induced Embryonic Stem Cell Differentiation

Peili Gu, Damien Le Menuet, Arthur Chung, +3

Molecular and Cellular Biology

CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion

Peili Gu, Jin‐Na Min, Yang Wang, +4

The EMBO Journal

ChromatinGenome InstabilityGene Deletion DataGeneticsStem Cell Exhaustion +10

SNMIB/Apollo protects leading‐strand telomeres against NHEJ‐mediated repair

Yung C. Lam, Shamima Akhter, Peili Gu, +7

The EMBO Journal

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

Bingbing Wan, Jinhu Yin, Kent Horvath, +11

Cell Reports

Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer

Cong Chen, Peili Gu, Jian Wu, +17

Nature Communications

Molecular characterization of an additional shrimp hyperglycemic hormone: cDNA cloning, gene organization, expression and biological assay of recombinant proteins¹

Peili Gu, Kei Li Yu, Siu‐Ming Chan

FEBS Letters

Functional characterization of human <scp>CTC</scp>1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease <scp>C</scp>oats plus

Peili Gu, Sandy Chang

Aging Cell

Mutations RevealsGenome InstabilityMendelian DisorderHuman Ctc1 MutationsGenetic Disorder +13