Ph. Coassolo

Integration of in Vitro Data into Allometric Scaling to Predict Hepatic Metabolic Clearance in Man: Application to 10 Extensively Metabolized Drugs

T. Lave, Sylvie Dupin, Christophe Schmitt et al. · Journal of Pharmaceutical Sciences · 1997 · 179 citations

The Use of Human Hepatocytes to Select Compounds Based on Their Expected Hepatic Extraction Ratios in Humans

T. Lave, Sylvie Dupin, Christophe Schmitt et al. · Pharmaceutical Research · 1997 · 105 citations

Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data

G. Ubeaud, Christophe Schmitt, D Jaeck et al. · Xenobiotica · 1995 · 45 citations

Interspecies scaling of tolcapone, a new inhibitor of catechol-<i>O</i>-methyltransferase (COMT). Use of<i>in vitro</i>data from hepatocytes to predict metabolic clearance in animals and humans

T. Lave, Sylvie Dupin, Monique Schmitt et al. · Xenobiotica · 1996 · 43 citations

Metabolomic Profiling, Metabolic Clearance, Physiologically-based Pharmacokinetic Modeling +24

Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry

C. Aubert, J P Sommadossi, Ph. Coassolo et al. · Journal of Mass Spectrometry · 1982 · 30 citations

Pathology, Gas Chromatography, Bioanalysis +18