Martin R. Osborne

(+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)-pyrene is an intermediate in the metabolism and binding to DNA of benzo(a)pyrene.

Hamish W. King, Martin R. Osborne, Frederick A. Beland et al. · Proceedings of the National Academy of Sciences · 1976 · 158 citations · Full text

Natural Sciences, Biochemistry, Chemistry +7

The reaction of (±)‐7α, 8β‐dihydroxy‐9β, 10β‐epoxy‐7,8,9,10‐tetrahydrobenzo(a)pyrene with dna

Martin R. Osborne, P. Brookes, Frederick A. Beland et al. · International Journal of Cancer · 1976 · 127 citations

Pharmacy, Biochemistry, Molecular Biology +16

Environmental Pollutant and Potent Mutagen 3-Nitrobenzanthrone Forms DNA Adducts after Reduction by NAD(P)H:Quinone Oxidoreductase and Conjugation by Acetyltransferases and Sulfotransferases in Human Hepatic Cytosols

Volker M. Arlt, Marie Stiborová, Colin J. Henderson et al. · Cancer Research · 2005 · 122 citations

Pharmacy, Biochemistry, Toxicology +15

Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen.

Martin R. Osborne, Alan Hewer, Ian R. Hardcastle et al. · PubMed · 1996 · 106 citations

Pharmacy, Pharmacology, Toxicology +16

Alkylation of DNA by the Nitrogen Mustard Bis-(2-chloroethyl)methylamine

Martin R. Osborne, D. E. V. Wilman, P.D. Lawley · Chemical Research in Toxicology · 1995 · 95 citations

Pharmacy, Chemistry, Toxicology +6