Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

Jacqueline M. Mason, Dan Lin, Wei Xin, +9

Cancer Cell

Chemoprevention StrategyMedicineReceptor Tyrosine KinasePotential Anticancer AgentPharmacology +10

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1<i>R</i>,2<i>S</i>)-2-(3-((<i>E</i>)-4-(((<i>cis</i>)-2,6-Dimethylmorpholino)methyl)styryl)-1<i>H</i>-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

Peter B. Sampson, Yong Liu, Bryan Forrest, +22

Journal of Medicinal Chemistry

Screening for Ligands Using a Generic and High-Throughput Light-Scattering-Based Assay

Guillermo Senisterra, Eugene Markin, Ken Yamazaki, +3

SLAS DISCOVERY

Transcription Elongation through DNA Arrest Sites

Donald E. Awrey, Rodney G. Weilbaecher, Sally A. Hemming, +3

Journal of Biological Chemistry

Mode of Action, <i>In Vitro</i> Activity, and <i>In Vivo</i> Efficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor

Nachum Kaplan, Monique Albert, Donald E. Awrey, +11

Antimicrobial Agents and Chemotherapy

The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3<i>H</i>]indol]-2′(1′<i>H</i>)-ones as Orally Bioavailable Antitumor Agents

Peter B. Sampson, Yong Liu, Narendra Kumar Patel, +21

Journal of Medicinal Chemistry

Pharmaceutical SciencePolo-like Kinase FamilyCompound 18Molecular BiologyPharmacotherapy +20

Hyperphosphorylation of Glucosyl C6 Carbons and Altered Structure of Glycogen in the Neurodegenerative Epilepsy Lafora Disease

Felix Nitschké, Peixiang Wang, Peter Schmieder, +10

Cell Metabolism

Neurodegenerative DiseasesAltered StructureBiochemistryGlycobiologyNeuroscience +6

Discovery of Pyrazolo[1,5-<i>a</i>]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent

Yong Liu, Radoslaw S. Laufer, Narendra Kumar Patel, +21

ACS Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceDrug TargetBiochemistryMedicine +12

Yeast Transcript Elongation Factor (TFIIS), Structure and Function

Donald E. Awrey, Nell Shimasaki, Rod Weilbaecher, +7

Journal of Biological Chemistry

The Discovery of PLK4 Inhibitors: (<i>E</i>)-3-((1<i>H</i>-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents

Radoslaw S. Laufer, Bryan Forrest, Sze-Wan Li, +21

Journal of Medicinal Chemistry

Molecular BiologyPharmacotherapyChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +16