Guillermo Senisterra

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Florian Grebien, Masoud Vedadi, Matthäus Getlik et al. · Nature Chemical Biology · 2015 · 282 citations · Full text

Hematological Malignancy, Medicine, Pharmacology +4

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

Mohammad S. Eram, Yudao Shen, Magdalena M. Szewczyk et al. · ACS Chemical Biology · 2015 · 280 citations · Full text

Drug Target, Epigenetic Change, Molecular Biology +23

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

Feng Liu, Xin Chen, Abdellah Allali‐Hassani et al. · Journal of Medicinal Chemistry · 2009 · 236 citations · Full text

Molecular Biology, Chemical Biology, Pharmaceutical Chemistry +17

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

Amy K. Wernimont, J.D. Artz, P.J. Finerty et al. · Nature Structural & Molecular Biology · 2010 · 235 citations · Full text

Protein Function, Molecular Physiology, Signal Transduction +12

The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

Yupeng He, Sujatha Selvaraju, Michael L. Curtin et al. · Nature Chemical Biology · 2017 · 229 citations · Full text

Protein Function, Signal Transduction, Molecular Regulation +7