Steven D. Fidanze

Discovery of <i>N</i>-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

Keith F. McDaniel, Le Wang, Todd Soltwedel et al. · Journal of Medicinal Chemistry · 2017 · 133 citations · Full text

Discovery of <i>N</i>-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

George S. Sheppard, Le Wang, Steven D. Fidanze et al. · Journal of Medicinal Chemistry · 2020 · 116 citations · Full text

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors

Le Wang, John K. Pratt, Todd Soltwedel et al. · Journal of Medicinal Chemistry · 2017 · 64 citations · Full text

Methylpyrrole inhibitors of BET bromodomains

Lisa Hasvold, George S. Sheppard, Le Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 19 citations · Full text

Medicinal Chemistry, Bet Bromodomains, Medicine +7

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors

Steven D. Fidanze, Dachun Liu, Robert A. Mantei et al. · Bioorganic & Medicinal Chemistry Letters · 2018 · 12 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Medicine +8