Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Byoung Dae Lee, Joo‐Ho Shin, Jackalina VanKampen, +9

Nature Medicine

MedicineAutophagyDegenerative PathologySystems BiologyPharmacology +2

Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease

Ian Martin, Jungwoo Wren Kim, Byoung Dae Lee, +14

Cell

Neurodegenerative DiseasesMolecular NeuroscienceSynaptic SignalingMolecular BiologyCell Death +6

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

Ho Chul Kang, Yun-Il Lee, Joo‐Ho Shin, +9

Proceedings of the National Academy of Sciences

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

Daniel A. Stevens, Yunjong Lee, Ho Chul Kang, +9

Proceedings of the National Academy of Sciences

MitophagyParis-dependent DeclinesDopamine NeuronsSynaptic SignalingSocial Sciences +24

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

Yunjong Lee, Senthilkumar S. Karuppagounder, Joo‐Ho Shin, +11

Nature Neuroscience

Molecular NeurosciencePhysiologyNeurotransmitterNeuroscienceDopamine +1

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

Zhaohui Liu, Shusei Hamamichi, Byoung Dae Lee, +7

Human Molecular Genetics

MitophagyCell DeathLrrk2 MutationsSignaling PathwayReceptor Tyrosine Kinase +15

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Yulan Xiong, Stewart Neifert, Senthilkumar S. Karuppagounder, +14

Proceedings of the National Academy of Sciences

Sensitization of Epidermal Growth Factor-induced Signaling by Bradykinin Is Mediated by c-Src

Eun-Mi Hur, Yongsoo Park, Byoung Dae Lee, +6

Journal of Biological Chemistry

Phosphorylation-dependent Regulation of Phospholipase D2 by Protein Kinase Cδ in Rat Pheochromocytoma PC12 Cells

Jung Min Han, Jae Ho Kim, Byoung Dae Lee, +9

Journal of Biological Chemistry

Phospholipase D2 Activity Suppresses Hydrogen Peroxide‐Induced Apoptosis in PC12 Cells

Sang Do Lee, Byoung Dae Lee, Jung Min Han, +4

Journal of Neurochemistry

Lipid PeroxidationApoptosisCell DeathCell Death MechanismsRedox Biology +17