Alexander F. Shaffer

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib:  A Potent and Selective Inhibitor of COX-2

John J. Talley, David Brown, Jeffery S. Carter et al. · Journal of Medicinal Chemistry · 2000 · 643 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

Comparative evaluation of arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation

Tadimeti S. Rao, J L Currie, Alexander F. Shaffer et al. · Inflammation · 1993 · 241 citations

Veterinary Medicine, Pharmacology, Inflammation +13

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor

Gabriel Mbalaviele, Adele M. Pauley, Alexander F. Shaffer et al. · Biochemical Pharmacology · 2010 · 64 citations

Life Sciences, Biochemistry, Pharmacology +11

A Novel, Highly Selective, Tight Binding IκB Kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear Factor-κB Pathway in Arthritis-Relevant Cells and Animal Models

Gabriel Mbalaviele, Cynthia D. Sommers, Sheri L. Bonar et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 61 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation

Graciela B. Arhancet, Daniel P. Walker, Sue Metz et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 48 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10