Mie Yoshimatsu

Discovery of 1-{4-[1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3- <i>d</i> ]pyrimidin-6-yl]phenyl}-3-methoxyurea (TAK-385) as a Potent, Orally Active, Non-Peptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Kazuhiro Miwa, Takenori Hitaka, Takashi Imada et al. · Journal of Medicinal Chemistry · 2011 · 100 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Suppression of the hypothalamic–pituitary–gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: Studies in human GnRH receptor knock-in mice

Daisuke Nakata, Tsuneo Masaki, Akira Tanaka et al. · European Journal of Pharmacology · 2013 · 72 citations

Medicine, Endocrinology, Pharmacology +14

Discovery of high-affinity BCL6-binding peptide and its structure-activity relationship

Kotaro Sakamoto, Satoshi Sogabe, Yusuke Kamada et al. · Biochemical and Biophysical Research Communications · 2016 · 36 citations

Pharmacy, Biochemistry, Medicinal Chemistry +14

Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-<i>a</i>]pyrazine Scaffold as a Novel Proline Mimetic

Kentaro Hashimoto, Bunnai Saito, Naoki Miyamoto et al. · Journal of Medicinal Chemistry · 2013 · 32 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells

Zenyu Shiokawa, Kentaro Hashimoto, Bunnai Saito et al. · Bioorganic & Medicinal Chemistry · 2013 · 22 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16