Concepedia

Suppression of the hypothalamic–pituitary–gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: Studies in human GnRH receptor knock-in mice

Daisuke Nakata, Tsuneo Masaki, Akira Tanaka, Mie Yoshimatsu, Y. Akinaga, Mari Asada, Reiko Sasada, Michiyasu Takeyama, Kazuhiro Miwa, Tatsuya Watanabe,

European Journal of Pharmacology · 2013 · 72 citations · 11 references

DOI

Concepts

References

11

A quantitative analysis of intron effects on mammalian gene expression

Ajit Nott, SHLOMO H. MEISLIN, Melissa J. Moore · RNA · 2003 · 418 citations · Full text

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Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11.

Kai Hsieh, Thomas F.J. Martin · Molecular Endocrinology · 1992 · 222 citations · Full text

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Discovery of a Thieno[2,3- <i>d</i> ]pyrimidine-2,4-dione Bearing a <i>p</i> -Methoxyureidophenyl Moiety at the 6-Position:  A Highly Potent and Orally Bioavailable Non-Peptide Antagonist for the Human Luteinizing Hormone-Releasing Hormone Receptor

Satoshi Sasaki, Nobuo Cho, Yoshi Nara et al. · Journal of Medicinal Chemistry · 2002 · 161 citations · Full text

, , +12

Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11

K. P. Hsieh · Molecular Endocrinology · 1992 · 125 citations

, , +14

Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix

R. Scott Struthers, Andrew Nicholls, John S. Grundy et al. · The Journal of Clinical Endocrinology & Metabolism · 2008 · 123 citations · Full text

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