Niels de Vries

Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity

Didier Meulendijks, Linda M. Henricks, Bart Jacobs et al. · British Journal of Cancer · 2017 · 122 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +15

Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Gene Dosage on Plasma Pharmacokinetics and Brain Accumulation of Dasatinib, Sorafenib, and Sunitinib

Seng Chuan Tang, Niels de Vries, Rolf W. Sparidans et al. · Journal of Pharmacology and Experimental Therapeutics · 2013 · 57 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Pronounced between‐subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers

Bart Jacobs, Maarten J. Deenen, Dick Pluim et al. · British Journal of Clinical Pharmacology · 2016 · 56 citations · Full text

Nursing, Biochemistry, Pharmacology +17

Dihydropyrimidine Dehydrogenase Phenotyping Using Pretreatment Uracil: A Note of Caution Based on a Large Prospective Clinical Study

Mirjam de With, Jonathan E. Knikman, Femke M. de Man et al. · Clinical Pharmacology & Therapeutics · 2022 · 56 citations · Full text

Medicine, Pharmacology, Clinical Pharmacology +14

Development and validation of a rapid and sensitive UPLC–MS/MS method for determination of uracil and dihydrouracil in human plasma

Bart Jacobs, Hilde Rosing, Niels de Vries et al. · Journal of Pharmaceutical and Biomedical Analysis · 2016 · 55 citations · Full text

Pharmacy, Pharmaceutical Analysis, Pharmacology +3