Seng Chuan Tang

Brain accumulation of sunitinib is restricted by P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration

Seng Chuan Tang, Jurjen S. Lagas, Nienke A. G. Lankheet et al. · International Journal of Cancer · 2011 · 159 citations

Medicine, Pharmacokinetics, Pharmacology +17

Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar

Seng Chuan Tang, Luan N. Nguyen, Rolf W. Sparidans et al. · International Journal of Cancer · 2013 · 144 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +16

Double-Transduced MDCKII Cells To Study Human P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Interplay in Drug Transport across the Blood−Brain Barrier

Birk Poller, Els Wagenaar, Seng Chuan Tang et al. · Molecular Pharmaceutics · 2011 · 72 citations

Medicine, Oncology, Pharmacology +16

Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Gene Dosage on Plasma Pharmacokinetics and Brain Accumulation of Dasatinib, Sorafenib, and Sunitinib

Seng Chuan Tang, Niels de Vries, Rolf W. Sparidans et al. · Journal of Pharmacology and Experimental Therapeutics · 2013 · 57 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Restrict Brain Accumulation of the Active Sunitinib Metabolite N-Desethyl Sunitinib

Seng Chuan Tang, Nienke A. G. Lankheet, Birk Poller et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 42 citations

Medicine, Pharmacokinetics, Pharmacology +17