DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis

Linda M. Henricks, Carin A.T.C. Lunenburg, Femke M. de Man, +28

The Lancet Oncology

MedicineProspective Safety AnalysisCancer ManagementPharmacotherapyCancer Treatment +7

Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity

Didier Meulendijks, Linda M. Henricks, Bart Jacobs, +11

British Journal of Cancer

DPYD genotype-guided dose individualization to improve patient safety of fluoropyrimidine therapy: call for a drug label update

Linda M. Henricks, Frans L. Opdam, J. H. Beijnen, +2

Annals of Oncology

Drug SafetyTherapeutic Drug MonitoringOncologyMedicinePatient Safety +4

A cost analysis of upfront DPYD genotype–guided dose individualisation in fluoropyrimidine-based anticancer therapy

Linda M. Henricks, Carin A.T.C. Lunenburg, Femke M. de Man, +28

European Journal of Cancer

Upfront DpydMedicineMetronomic TherapyPharmacologyPharmacotherapy +6

RasGRP1 opposes proliferative EGFR–SOS1–Ras signals and restricts intestinal epithelial cell growth

Philippe Depeille, Linda M. Henricks, Robert A. H. van de Ven, +8

Nature Cell Biology

Cancer ResearchSignaling PathwayProliferative Egfr–sos1–ras SignalsPathologyCell Growth +7

Effectiveness and safety of reduced‐dose fluoropyrimidine therapy in patients carrying the <i>DPYD</i>*2A variant: A matched pair analysis

Linda M. Henricks, Lisanne N. van Merendonk, Didier Meulendijks, +5

International Journal of Cancer

Genetic EpidemiologyPharmacotherapyFull Fluoropyrimidine DoseGenetic MedicinePre-clinical Pharmacology +16

Development and validation of a rapid and sensitive UPLC–MS/MS method for determination of uracil and dihydrouracil in human plasma

Bart Jacobs, Hilde Rosing, Niels de Vries, +4

Journal of Pharmaceutical and Biomedical Analysis

BiochemistryMedicineBioanalysisMass SpectrometryHuman Plasma +8

Dihydropyrimidine Dehydrogenase Phenotyping Using Pretreatment Uracil: A Note of Caution Based on a Large Prospective Clinical Study

Mirjam de With, Jonathan E. Knikman, Femke M. de Man, +19

Clinical Pharmacology & Therapeutics

Survival of Patients With Cancer With <i>DPYD</i> Variant Alleles and Dose-Individualized Fluoropyrimidine Therapy—A Matched-Pair Analysis

Jonathan E. Knikman, Tycho A. Wilting, Marta López‐Yurda, +21

Journal of Clinical Oncology

Food‐effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers

Linda M. Henricks, Bart Jacobs, Didier Meulendijks, +9

British Journal of Clinical Pharmacology