Colin Howes

Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo

Susan Ashton, Young Ho Song, Elaine Cadogan et al. · Science Translational Medicine · 2016 · 220 citations

Pharmacy, Oncology, Pharmacology +17

Oral administration of a potent and selective non‐peptidic BACE‐1 inhibitor decreases β‐cleavage of amyloid precursor protein and amyloid‐β production <i>in vivo</i>

Ishrut Hussain, Julie A. Hawkins, David C. Harrison et al. · Journal of Neurochemistry · 2006 · 198 citations · Full text

Life Sciences, Neuroscience, Pharmacology +14

The Identification of Indacaterol as an Ultralong-Acting Inhaled β₂-Adrenoceptor Agonist

François Baur, David T. Beattie, David Beer et al. · Journal of Medicinal Chemistry · 2010 · 104 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Secondary bonding. Part 13. Aryl-tellurium(<scp>IV</scp>) and -iodine(<scp>III</scp>) acetates and trifluoroacetates. The crystal and molecular structures of bis-(p-methoxyphenyl)tellurium diacetate, µ-oxo-bis[diphenyltrifluoroacetoxytellurium] hydrate, and [bis(trifluoroacetoxy)iodo]benzene

Nathaniel W. Alcock, W. Harrison, Colin Howes · Journal of the Chemical Society Dalton Transactions · 1984 · 70 citations

Natural Sciences, Chemistry, Crystal Structure +13

Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability

Nicolas Charrier, Brian Clarke, Leanne Cutler et al. · Journal of Medicinal Chemistry · 2008 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15