Brian Clarke - Concepedia

Author

Brian Clarke

GlaxoSmithKline (United Kingdom)

Also Known As

B Clarke, B. CLARKE, B. Clarke, B. P. CLARKE, B.P. Clarke, Brian Clarke, Brian P. Clarke

Publications

2.1K

Citations

H-Index

Concepts

All Affiliations

GlaxoSmithKline (United Kingdom)University of Nottingham University of Virginia The University of Western Australia New Frontier

About

Brian Clarke is an author at GlaxoSmithKline (United Kingdom) specializing in medicine, natural sciences, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	15	16	1.1K
2	Natural Sciences	11	11	774
3	Engineering	3	3	118
4	Arts	1	1	24
5	Language Studies	1	1	24

Brian Clarke

Publications

1.9K

Citations

H-Index

Page 1

	Year	Citations
Crystal Structure of the IMP-1 Metallo β-Lactamase from <i>Pseudomonas aeruginosa</i> and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent, Broad-Spectrum Inhibitor<sup>,</sup> N.O. Concha, Cheryl A. Janson, P. Rowling, Biochemistry	2000	303
The contribution of ecological genetics to evolutionary theory: detecting the direct effects of natural selection on particular polymorphic loci. Brian Clarke PubMed Ecological GeneticsGeneticsNatural SelectionBiological EvolutionMolecular Ecology	1975	250
Extreme divergence of mitochondrial DNA within species of pulmonate land snails Diogo Thomaz, Annie Guiller, Brian Clarke Proceedings of the Royal Society B Biological Sciences Molecular Evolutionary EcologyDnaMitochondrial DiversityGeneticsDna Analysis	1996	241
Characterization of the Glycosylation Profiles of Alzheimer's β-Secretase Protein Asp-2 Expressed in a Variety of Cell Lines Joanne Charlwood, Colin Dingwall, Rosalie Matico, Journal of Biological Chemistry Protein SecretionGlycobiologyMolecular BiologyGlycosylation ProfilesAmyloid Precursor Protein	2001	94
The genus <i>Partula</i> on Moorea: speciation in progress J. D. Murray, Brian Clarke Proceedings of the Royal Society of London. Series B, Biological sciences	1980	76
Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators Simon E. Ward, Mark H Harries, Laura Aldegheri, Journal of Medicinal Chemistry Proteinlipid InteractionAmpar Positive ModulatorsHigh ThroughputChemical BiologyMedicinal Chemistry	2010	65
Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability Nicolas Charrier, Brian Clarke, Leanne Cutler, Journal of Medicinal Chemistry Pharmaceutical ScienceOral BioavailabilityNeurochemical BiomarkersPharmacotherapyPharmaceutical Chemistry	2008	64
The Legion Grid Portal Anand Natrajan, Anh Nguyen‐Tuong, Marty Humphrey, Concurrency and Computation Practice and Experience Cluster ComputingEngineeringSoftware EngineeringData GridGrid Database	2002	61
Evidence for Apostatic Selection by Predators using Olfactory Cues Ian Soane, Brian Clarke Nature Animal BehaviourBehavioral NeurosciencePredator-prey InteractionEvolutionary BiologyOlfactory Cues	1973	59
BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells Paul Beswick, Nicolas Charrier, Brian Clarke, Bioorganic & Medicinal Chemistry Letters Medicinal ChemistryPharmaceutical ScienceBiochemistryNanomolar PotencyMedicine	2008	57

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