David Beer

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

Kévin Pethe, Patrícia Carvalho de Sequeira, Sanjay Agarwalla et al. · Nature Communications · 2010 · 308 citations · Full text

Pharmacy, Medicinal Chemistry, Microbiology +12

Functional Profiling of Recombinant NS3 Proteases from All Four Serotypes of Dengue Virus Using Tetrapeptide and Octapeptide Substrate Libraries

Jun Li, Siew Pheng Lim, David Beer et al. · Journal of Biological Chemistry · 2005 · 249 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease

E. Schmitt, Meliana Riwanto, Vasan K. Sambandamurthy et al. · Angewandte Chemie International Edition · 2011 · 199 citations

Medicine, Molecular Biology, Pharmacology +6

Peptide inhibitors of dengue virus NS3 protease. Part 1: Warhead

Zheng Yin, Sejal Patel, Weiling Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 157 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +14

Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors

Zheng Yin, Sejal Patel, Weiling Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 152 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +13