A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

Kévin Pethe, Patrícia Carvalho de Sequeira, Sanjay Agarwalla, +38

Nature Communications

Bioorganic ChemistryTuberculosis PreventionBacteriologyMolecular BiologyVivo Efficacy +22

Functional Profiling of Recombinant NS3 Proteases from All Four Serotypes of Dengue Virus Using Tetrapeptide and Octapeptide Substrate Libraries

Jun Li, Siew Pheng Lim, David Beer, +9

Journal of Biological Chemistry

The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease

E. Schmitt, Meliana Riwanto, Vasan K. Sambandamurthy, +14

Angewandte Chemie International Edition

Peptide inhibitors of dengue virus NS3 protease. Part 1: Warhead

Zheng Yin, Sejal Patel, Weiling Wang, +11

Bioorganic & Medicinal Chemistry Letters

ImmunologyAntiviral Drug DevelopmentVirologyAntiviral DrugViral Structural Protein +3

Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors

Zheng Yin, Sejal Patel, Weiling Wang, +12

Bioorganic & Medicinal Chemistry Letters

Antiviral CompoundBiochemistryAntiviral Drug DevelopmentSar StudyVirology +7

Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis

Srinivasa P. S. Rao, Suresh B. Lakshminarayana, Ravinder Reddy Kondreddi, +34

Science Translational Medicine

Tuberculosis PreventionPharmacotherapyAntimicrobial ChemotherapyDrug ResistanceMultidrug-resistant Tuberculosis +16

Direct inhibitors of InhA are active against <i>Mycobacterium tuberculosis</i>

Ujjini H. Manjunatha, Srinivasa P. S. Rao, Ravinder Reddy Kondreddi, +18

Science Translational Medicine

Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput Docking

Dariusz Ekonomiuk, Xun‐Cheng Su, Kiyoshi Ozawa, +9

PLoS neglected tropical diseases

A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating <i>Mycobacterium tuberculosis</i>

Puiying A. Mak, Srinivasa P. S. Rao, Mai Ping Tan, +23

ACS Chemical Biology

Bioorganic ChemistryMolecular BiologyChemical BiologyRedox BiologyAtp Homeostasis +17

A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease

Christophe Bodenreider, David Beer, Thomas H. Keller, +14

Analytical Biochemistry

BiochemistryDengue Virus ProteaseBioanalysisAntiviral Drug DevelopmentVirology +7