Exosomes: roles and therapeutic potential in osteoarthritis

Zhenhong Ni, Siru Zhou, Song Li, +7

Bone Research

Therapeutic PotentialImmunologyBone RepairExtracellular MicrovesiclesOa Joint +17

The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis

Zhenhong Ni, Liang Kuang, Hangang Chen, +14

Cell Death and Disease

SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1β and contributes to LIPUS-mediated anti-inflammatory effect

Bin Zhang, Hangang Chen, Junjie Ouyang, +2

Autophagy

Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice

Junzhou Tang, Nan Su, Siru Zhou, +9

Arthritis & Rheumatology

FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice

Liang Kuang, Jiangyi Wu, Nan Su, +14

Annals of the Rheumatic Diseases

Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway

Xianding Sun, Yang Zhou, Ruobin Zhang, +22

Nature Communications

FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling

Siru Zhou, Yangli Xie, Junzhou Tang, +11

PLoS Genetics

FibrosisDevelopmental BiologyBone Morphogenic ProteinIndian HedgehogFgfr3 Function +9

Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice

Siru Zhou, Yangli Xie, Wei Li, +17

Scientific Reports

Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint

Zuqiang Wang, Junlan Huang, Siru Zhou, +8

Journal of Biological Chemistry

<i>Fgfr3</i> mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling

Xianding Sun, Ruobin Zhang, Hangang Chen, +19

Theranostics