Frank Chavez

Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors

Liping H. Pettus, Kristin L. Andrews, Shon K. Booker et al. · Journal of Medicinal Chemistry · 2016 · 39 citations · Full text

Pharmaceutical Science, Cell Death, Pharmacotherapy +16

Discovery and SAR of 6-Alkyl-2,4-diaminopyrimidines as Histamine H₄ Receptor Antagonists

Brad M. Savall, Frank Chavez, Kevin L. Tays et al. · Journal of Medicinal Chemistry · 2014 · 37 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Allergy +13

The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors

Huiling Wang, Victor J. Cee, Frank Chavez et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 35 citations · Full text

Medicinal Chemistry, Medicine, Drug Discovery +8

Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors

Victor J. Cee, Frank Chavez, Bradley J. Herberich et al. · ACS Medicinal Chemistry Letters · 2016 · 28 citations · Full text

Combinatorial Chemistry, Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones, Pim-1/2 Kinase Overexpression +16

Discovery of (<i>R</i>)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-<i>b</i>]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3<i>H</i>)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies

Hui-Ling Wang, Kristin L. Andrews, Shon K. Booker et al. · Journal of Medicinal Chemistry · 2019 · 25 citations

Pim Kinases, Pharmacotherapy, Hematological Malignancies +16