Graham L. Smith

Discovery of (10 <i>R</i> )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- <i>2H</i> -8,4-(metheno)pyrazolo[4,3- <i>h</i> ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

Ted W. Johnson, Paul Richardson, Simon Bailey et al. · Journal of Medicinal Chemistry · 2014 · 571 citations · Full text

Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib

Qinhua Huang, Ted W. Johnson, Simon Bailey et al. · Journal of Medicinal Chemistry · 2014 · 115 citations · Full text

Aminopyridine 8E, Tumor Biology, Kinase Domain +14

Development of Scalable Syntheses of Selective PI3K inhibitors

Qinhua Huang, Paul Richardson, Neal W. Sach et al. · Organic Process Research & Development · 2011 · 45 citations

Combinatorial Chemistry, Medicinal Chemistry, Pharmaceutical Chemistry +11

Design and Synthesis of Novel <i>N</i>-Hydroxy-Dihydronaphthyridinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors

Ted W. Johnson, Steven P. Tanis, Scott L. Butler et al. · Journal of Medicinal Chemistry · 2011 · 43 citations · Full text

Hiv-1 In Inhibitors, Medicinal Chemistry, Hiv-1 Integrase +15

Highly Selective and Potent Thiophenes as PI3K Inhibitors with Oral Antitumor Activity

Kevin Liu, JinJiang Zhu, Graham L. Smith et al. · ACS Medicinal Chemistry Letters · 2011 · 39 citations · Full text

Pi3k Inhibitors, Pharmacotherapy, Pharmaceutical Chemistry +20