Neal W. Sach

Practical and innate carbon–hydrogen functionalization of heterocycles

Yuta Fujiwara, Janice A. Dixon, Fionn O’Hara et al. · Nature · 2012 · 910 citations · Full text

Organic Chemistry, Organometallic Catalysis, Carbon–hydrogen Functionalization +1

Discovery of (10 <i>R</i> )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- <i>2H</i> -8,4-(metheno)pyrazolo[4,3- <i>h</i> ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations

Ted W. Johnson, Paul Richardson, Simon Bailey et al. · Journal of Medicinal Chemistry · 2014 · 571 citations · Full text

Strain-release amination

Ryan Gianatassio, Justin M. Lopchuk, Jie Wang et al. · Science · 2016 · 546 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Bioorganic Chemistry +11

A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow

Damith Perera, Joseph W. Tucker, Shalini Brahmbhatt et al. · Science · 2018 · 478 citations

Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Yu Kawamata, Julien C. Vantourout, David P. Hickey et al. · Journal of the American Chemical Society · 2019 · 345 citations · Full text