Fabio Pacchiano

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

Yuanmei Lou, Paul C. McDonald, Arusha Oloumi et al. · Cancer Research · 2011 · 756 citations

Medicine, Oncology, Pharmacology +17

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

Fabio Pacchiano, Fabrizio Carta, Paul C. McDonald et al. · Journal of Medicinal Chemistry · 2011 · 514 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

Fabio Pacchiano, Mayank Aggarwal, Balendu Sankara Avvaru et al. · Chemical Communications · 2010 · 217 citations

Pharmacy, Biochemistry, Medicinal Chemistry +15

Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides

Fabio Pacchiano, Fabrizio Carta, Daniela Vullo et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 38 citations · Full text

Life Sciences, Biochemistry, Pharmacology +7

Carbonic anhydrase inhibitors: 2-Substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV

Fatma-Zohra Smaine, Fabio Pacchiano, Marouan Rami et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 31 citations · Full text

Life Sciences, Biochemistry, Pharmacology +12