Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in Vivo

Fabrizio Carta, Mayank Aggarwal, Alfonso Maresca, +4

Journal of Medicinal Chemistry

Bioorganic ChemistryGlycobiologyPharmacotherapyChemical BiologyExperimental Pharmacology +14

Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

Fabio Pacchiano, Mayank Aggarwal, Balendu Sankara Avvaru, +4

Chemical Communications

Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

Fabrizio Carta, Mayank Aggarwal, Alfonso Maresca, +3

Chemical Communications

Combinatorial ChemistryOrganic ChemistryChemistryChemical BiologyPharmaceutical Chemistry +14

Insights towards sulfonamide drug specificity in α-carbonic anhydrases

Mayank Aggarwal, Bhargav Kondeti, Robert McKenna

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical Scienceα-Carbonic AnhydrasesBiochemistryNatural Sciences +5

Neutron Diffraction of Acetazolamide-Bound Human Carbonic Anhydrase II Reveals Atomic Details of Drug Binding

S. Zoë Fisher, Mayank Aggarwal, Andrey Kovalevsky, +2

Journal of the American Chemical Society

X-ray CrystallographyNeutron DiffractionCa IsoformsChemical BiologyMedicinal Chemistry +14

Anticonvulsant 4-Aminobenzenesulfonamide Derivatives with Branched-Alkylamide Moieties: X-ray Crystallography and Inhibition Studies of Human Carbonic Anhydrase Isoforms I, II, VII, and XIV

Naama Hen, Meir Bialer, Boris Yagen, +6

Journal of Medicinal Chemistry

X-ray CrystallographyPharmaceutical ScienceBioorganic ChemistryPharmacotherapyPharmaceutical Chemistry +16

Lactate flux in astrocytes is enhanced by a non‐catalytic action of carbonic anhydrase II

Malin H. Stridh, Marco D. Alt, Sarah Wittmann, +8

The Journal of Physiology

Rapid ExchangeCarbonic Anhydrase IiCellular PhysiologySocial SciencesBioenergetics +19

Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry

Nicolino Pala, Laura Micheletto, Mario Sechi, +4

ACS Medicinal Chemistry Letters

Combinatorial ChemistryBioorganic ChemistryXii IsoformsOrganic ChemistryClick Chemistry +18

Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II

C. D. Boone, Moanaro Biswas, Balasubramanian Venkatakrishnan, +5

Protein Engineering Design and Selection

Structural CharacterizationEngineeringBiochemistryCarbon Dioxide HydrationBioenergetics +13

Water Networks in Fast Proton Transfer during Catalysis by Human Carbonic Anhydrase II

Rose Mikulski, D.M. West, Katherine H. Sippel, +5

Biochemistry

EngineeringProton-coupled Electron TransferMolecular BiologyChemistryAnalytical Ultracentrifugation +19