Paul C. McDonald

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

Fabio Pacchiano, Fabrizio Carta, Paul C. McDonald et al. · Journal of Medicinal Chemistry · 2011 · 514 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

Frances E. Lock, Paul C. McDonald, Y. Lou et al. · Oncogene · 2012 · 345 citations

Medicine, Molecular Biology, Oncology +16

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors

Paul C. McDonald, Stephen Chia, Philippe L. Bédard et al. · American Journal of Clinical Oncology · 2020 · 250 citations · Full text

Medicine, Oncology, Pharmacology +16

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

Paul C. McDonald, Shawn C. Chafe, Wells S. Brown et al. · Gastroenterology · 2019 · 232 citations · Full text

Medicine, Cancer Biology, Oncology +17

Rictor and Integrin-Linked Kinase Interact and Regulate Akt Phosphorylation and Cancer Cell Survival

Paul C. McDonald, Arusha Oloumi, Julia Mills et al. · Cancer Research · 2008 · 227 citations · Full text

Life Sciences, Cell Biology, Oncology +11