Shawn C. Chafe

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

Chi-Hong Wu, Claudia Fallini, Nicola Ticozzi et al. · Nature · 2012 · 599 citations

Life Sciences, Genetics, Neuroscience +12

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche

Frances E. Lock, Paul C. McDonald, Y. Lou et al. · Oncogene · 2012 · 345 citations

Medicine, Molecular Biology, Oncology +16

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

Paul C. McDonald, Shawn C. Chafe, Wells S. Brown et al. · Gastroenterology · 2019 · 232 citations · Full text

Medicine, Cancer Biology, Oncology +17

Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically

Shawn C. Chafe, Paul C. McDonald, Saeed Saberi et al. · Cancer Immunology Research · 2019 · 161 citations

Medicine, Immunology, Oncology +17

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors

Shawn C. Chafe, Frederick S. Vizeacoumar, Geetha Venkateswaran et al. · Science Advances · 2021 · 139 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +16