Carl Ng

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark et al. · Nature Biotechnology · 2008 · 1.3K citations

Medicinal Chemistry, Immunocytochemical Technique, Drug Targeting +10

Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates

Leanna R. Staben, Stefan G. Koenig, Sophie M. Lehar et al. · Nature Chemistry · 2016 · 147 citations

Medicinal Chemistry, Antibody–drug Conjugates, Drug Targeting +8

High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

Rachana Ohri, Sunil Bhakta, Aimee Fourie-O’Donohue et al. · Bioconjugate Chemistry · 2018 · 109 citations

Molecular Biology, Immunochemistry, Antibody Engineering +16

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

Peter S. Dragovich, Pragya Adhikari, Robert A. Blake et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 102 citations

Hormonal Receptor, Estrogen Receptor Alpha, Immunology +9

Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification

Dian Su, Katherine R. Kozak, Jack Sadowsky et al. · Bioconjugate Chemistry · 2018 · 76 citations

Medicinal Chemistry, Drug Targeting, Engineering +15