Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

Chi Ma, Miaojun Han, Bernd Heinrich, +20

Science

Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma

Qianfei Zhang, Chi Ma, Yi Duan, +28

Cancer Discovery

Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived suppressor cells in hepatocellular carcinoma

Su Jong Yu, Chi Ma, Bernd Heinrich, +8

Journal of Hepatology

Tumor BiologyMedicineImmunologyMyeloid-derived Suppressor CellsImmune Checkpoint Inhibitor +7

Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development

Zachary J. Brown, Qiong Fu, Chi Ma, +10

Cell Death and Disease

Surveying a supercoil domain by using the gamma delta resolution system in Salmonella typhimurium

N. Patrick Higgins, Xiangli Yang, Qiong Fu, +1

Journal of Bacteriology

Indoleamine 2,3-dioxygenase provides adaptive resistance to immune checkpoint inhibitors in hepatocellular carcinoma

Zachary J. Brown, Su Jong Yu, Bernd Heinrich, +7

Cancer Immunology Immunotherapy

Checkpoint InhibitorsHepatocellular CarcinomaMedicineLiver PhysiologyImmunology +7

Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD

Chi Ma, Qiong Fu, Laurence P. Diggs, +19

Cancer Cell

InflammationHepatologyLiver PhysiologyPathologyVascular Biology +10

Steatohepatitis Impairs T-cell–Directed Immunotherapies Against Liver Tumors in Mice

Bernd Heinrich, Zachary J. Brown, Laurence P. Diggs, +14

Gastroenterology

Cancer ImmunosurveillanceHepatologyLiver PhysiologyImmunologyTumor Immunity +6

Sae2/CtIP prevents R-loop accumulation in eukaryotic cells

Nodar Makharashvili, Sucheta Arora, Yizhi Yin, +7

eLife

Dna Double-strand BreaksMolecular RegulationMolecular BiologySae2/ctip ProteinCellular Physiology +15

Phosphorylation-Regulated Transitions in an Oligomeric State Control the Activity of the Sae2 DNA Repair Enzyme

Qiong Fu, Julia Chow, Kara A. Bernstein, +6

Molecular and Cellular Biology

EngineeringMolecular BiologyCell CycleOligomeric State ControlAutophagy +14