Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

Chi Ma, Miaojun Han, Bernd Heinrich, +20

Science

Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma

Qianfei Zhang, Chi Ma, Yi Duan, +28

Cancer Discovery

Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived suppressor cells in hepatocellular carcinoma

Su Jong Yu, Chi Ma, Bernd Heinrich, +8

Journal of Hepatology

Tumor BiologyMedicineImmunologyMyeloid-derived Suppressor CellsImmune Checkpoint Inhibitor +7

CCL5-Mediated Th2 Immune Polarization Promotes Metastasis in Luminal Breast Cancer

Qianfei Zhang, Jilong Qin, Lin Zhong, +4

Cancer Research

Breast OncologyImmunologyImmune RegulationImmunotherapeuticsImmunotherapy +15

CD40-mediated immune cell activation enhances response to anti-PD-1 in murine intrahepatic cholangiocarcinoma

Laurence P. Diggs, Benjamin Ruf, Chi Ma, +17

Journal of Hepatology

Murine Intrahepatic CholangiocarcinomaCancer ImmunosurveillanceAutoimmune DiseaseBiliary CancerLiver Physiology +9

Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development

Zachary J. Brown, Qiong Fu, Chi Ma, +10

Cell Death and Disease

Indoleamine 2,3-dioxygenase provides adaptive resistance to immune checkpoint inhibitors in hepatocellular carcinoma

Zachary J. Brown, Su Jong Yu, Bernd Heinrich, +7

Cancer Immunology Immunotherapy

Checkpoint InhibitorsHepatocellular CarcinomaMedicineLiver PhysiologyImmunology +7

Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD

Chi Ma, Qiong Fu, Laurence P. Diggs, +19

Cancer Cell

InflammationHepatologyLiver PhysiologyPathologyVascular Biology +10

Steatohepatitis Impairs T-cell–Directed Immunotherapies Against Liver Tumors in Mice

Bernd Heinrich, Zachary J. Brown, Laurence P. Diggs, +14

Gastroenterology

Cancer ImmunosurveillanceHepatologyLiver PhysiologyImmunologyTumor Immunity +6

Activating Mucosal-Associated Invariant T Cells Induces a Broad Antitumor Response

Benjamin Ruf, Vanessa V. Catania, Simon Wabitsch, +14

Cancer Immunology Research