Robert A. Copeland

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Cancer Cell · 2011 · 923 citations · Full text

Hematological Malignancy, Tumor Biology, Selective Killing +8

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

Sarah K. Knutson, Natalie M. Warholic, Tim J. Wigle et al. · Proceedings of the National Academy of Sciences · 2013 · 757 citations · Full text

Engineering, Chemoprevention Strategy, Smarcb1-deleted Mrt Cells +24

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

Sarah K. Knutson, Tim J. Wigle, Natalie M. Warholic et al. · Nature Chemical Biology · 2012 · 753 citations

Lymphoid Neoplasia, Medicine, Selective Inhibitor +8

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Blood · 2013 · 718 citations · Full text

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

Christopher J. Sneeringer, Margaret Porter Scott, Kevin W. Kuntz et al. · Proceedings of the National Academy of Sciences · 2010 · 675 citations · Full text