Xiaofeng Zhao

Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine <i>C</i>-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV

Richard L. Mackman, Hon C. Hui, Michel Perron et al. · Journal of Medicinal Chemistry · 2021 · 90 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

Ruidong Li, Albert Liclican, Yili Xu et al. · Antimicrobial Agents and Chemotherapy · 2021 · 63 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

Meghan S. Vermillion, Eisuke Murakami, Bin Ma et al. · Science Translational Medicine · 2021 · 42 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo

Congrong Niu, Yujin Wang, Xiaofeng Zhao et al. · Drug Metabolism and Disposition · 2019 · 27 citations

Medicine, Molecular Biology, Pharmacology +13

Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition

Jennifer Tang, Hong Shen, Xiaofeng Zhao et al. · Drug Metabolism and Disposition · 2021 · 27 citations

Medicine, Pharmacokinetics, Pharmacology +14