Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

Sebastian Mueller, Thomas Engleitner, Roman Maresch, +46

Nature

Pancreatic CancerEvolutionary RoutesMedicinePathologyOncology +2

Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer

Stefan Eser, Nina Reiff, Marlena Messer, +19

Cancer Cell

Tumor BiologySignal TransductionSignaling PathwayPancreatic CancerCell Regulation +9

E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex

Johannes von Burstin, Stefan Eser, Mariel C. Paul, +11

Gastroenterology

Tumor BiologySignaling PathwaySnail/hdac1/hdac2 Repressor ComplexPancreatic CancerE-cadherin Regulates Metastasis +9

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Nina Schönhuber, Barbara Seidler, Kathleen Schuck, +24

Nature Medicine

Tumor BiologyHost-specific TargetingNext-generation Dual-recombinase SystemEngineeringPancreatic Cancer +8

A Genetic Progression Model of BrafV600E-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention

Roland Rad, Juan Cadiñanos, Lena Rad, +23

Cancer Cell

Tumor BiologyMedicineImmunologyPathologyColorectal Cancer +7

A Porcine Model of Familial Adenomatous Polyposis

Tatiana Flisikowska, Claudia Merkl, Martina Landmann, +13

Gastroenterology

Porcine ModelGenetic DisorderSurgical PathologyPathologyMolecular Pathology +3

In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging

Stefan Eser, Marlena Messer, Philipp Eser, +13

Proceedings of the National Academy of Sciences

EngineeringOncologic ImagingPathologyEndoscopic ImagingOncology +15

Highly sensitive detection of early‐stage pancreatic cancer by multimodal near‐infrared molecular imaging in living mice

Johannes von Burstin, Stefan Eser, Barbara Seidler, +9

International Journal of Cancer

Imaging BiomarkersEngineeringOncologic ImagingPathologyTumor Biology +17

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer

Roland Rad, Lena Rad, Wei Wang, +42

Nature Genetics

Knockout MousePancreatic CancerOncogenic AgentGeneticsCancer Genomics +7

A porcine model of osteosarcoma

Anja Saalfrank, KP Janssen, Morgane Ravon, +16

Oncogenesis

Porcine ModelDevelopmental BiologyLatent Oncogenic Tp53Malignant DiseaseMedicine +13